Arthur M. Mercurio

Detection of Single-Stranded DNA Gaps Reveals a Functional Biomarker of Therapeutic Response

Single-stranded DNA (ssDNA) gaps represent an underappreciated vulnerability that directly shapes therapeutic response in BRCA-deficient models. Current clinical biomarkers remain anchored to the double-strand break (DSB) centric model of homologous recombination deficiency (HRD)...