Arthur M. J. David

Enantioselective Access to the Parent Helicenols by Kinetic Resolution through Cu–H-Catalyzed Si–O Coupling

Abstract A Cu–H-catalyzed kinetic resolution of the parent [n]helicenols (n = 5, 6) through enantioselective dehydrogenative silylation with a secondary silane is reported. The dihydrosilane eventually employed is prochiral, thereby simultaneously establishing stereogenicity at t...