Arthur M. Albuquerque

Sequential randomization tests using e-values for clinical trial monitoring across endpoint types

Abstract Background In randomized trials, repeated interim analyses of accumulating data must keep the Type I error controlled. Sequential analyses that use e-values allow continuous assessment of evidence while controlling their own Type I error. We present e-RT, a randomization...

Cefepime and Mortality

Importance Cefepime is recommended for the treatment of febrile neutropenia and gram-negative infections at moderate risk of ampicillin resistance locus C β-lactamase production. Concerns regarding cefepime’s safety have been raised in the literature without firm conclusions. Obj...