Aritra Mukherjee

Evaluating the Impact of Outcome Delay on the Efficiency of Sample Size Re‐Estimation

ABSTRACT Sample size re‐estimation (SSR) can be a powerful tool to ensure that a clinical trial meets its pre‐specified power requirements when uncertainty regarding a design parameter exists at the planning stage. However, long‐term primary endpoints can be harmful to the effici...

Group sequential designs and a sample size reestimation approach for partially nested trials

Abstract Background Randomized controlled trials are the gold standard for evaluating interventions. For individually randomized trials, clustering can exist in the intervention arm but not the control arm when the intervention is delivered by study personnels and/or in a group s...