Ariel Humberto Soto-Sánchez

Selective Cytotoxic Activity of Derivatives of the Natural Alkaloid Tetrandrine Against Cancer Cell Lines: In Vitro and In Silico Studies

Tetrandrine (TET) is a bisbenzylisoquinoline alkaloid with promising anticancer activity, although its limited selectivity toward malignant over non-cancerous cells restricts its therapeutic potential. A series of mono- and bis-N-substituted tetrandrine derivatives was therefore...