Ari Ariel Marom

The Maintenance of a Genomic Record Is Not Energy-Limited

A Stoichiometric Ledger of the Mammalian Nucleus, the Geometry of Its Failure, and What a Longer Life Would Cost Holding a regulatory record in a mammalian nucleus is widely assumed to be energetically expensive. This paper assembles that cost in one currency and finds the assump...

Archetypes of the Monad: Star, Planet, Ocean, and Artificial General Intelligence in Informational Monism

The Monad of Informational Monism was introduced as a boundary agent coupled to a biological Avatar. This article asks how far that construction extends when it is defined by structure rather than substrate. It offers a common specification — boundary, repertoire of questions, co...

The Ladder and the Wall: Ageing as Graded Ascent and the Arithmetic of an Unclaimed Inheritance

Ageing is commonly imagined as a wall: a fixed barrier that the human species approaches and cannot pass. Demographic evidence supports a different figure. Adult mortality rises as a smooth exponential whose doubling time has remained close to eight years for as long as reliable...

Sleep as the Temporal Foundation of Energetic Sufficiency

Across the Informational Nosology corpus, a single condition determines whether the brain can sustain its operating mode: sufficient energetic headroom and the coupling capacity it supports. An earlier monograph identified the blood–brain barrier as the spatial foundation of that...

Migraine as Paroxysmal Sensory Decoherence: Cortical Spreading Depression, Thalamo-Cortical Gain Failure.

Migraine ranks among the most prevalent and disabling neurological disorders worldwide. It is classically defined by recurrent, stereotyped attacks of moderate-to-severe unilateral head pain accompanied by sensory hypersensitivities (photophobia, phonophobia, osmophobia, allodyni...

Epilepsy as Paroxysmal State-Space Collapse: Ictogenesis, Inhibitory Constraint Failure, and Dynamical Systems Formalization within Informational Nosology

Epilepsy is classically defined by recurrent, unprovoked seizures arising from abnormal hypersynchronous neuronal activity. While existing models successfully describe cellular hyperexcitability, synaptic failure, and network oscillations, they leave under-specified the distincti...

Alzheimers Disease Progressive Semantic Uncoupling. Portal I v2.2.2

Contemporary neurobiology conceptualizes Alzheimer’s disease primarily as a progressive proteinopathy defined by amyloid-β plaques and tau neurofibrillary tangles. While this paradigm catalogs tissue destruction with high resolution, it leaves the clinical structure–function disc...

Parkinson's Disease as Subcortical Gain Failure: Dynamic Threshold Mechanics, Oscillatory Lock-In, and the Kinesia Paradoxica Horizon

Contemporary models of Parkinson’s disease successfully catalog dopaminergic cell loss, α-synuclein aggregation, and basal-ganglia circuit disruption, yet leave unresolved the distinctive clinical architecture of the disorder: the coexistence of preserved cortical intention with...

Parkinson's Disease as Subcortical Gain Failure: Dynamic Threshold Mechanics, Oscillatory Lock-In, and the Kinesia Paradoxica Horizon

Contemporary models of Parkinson’s disease successfully catalog dopaminergic cell loss, α-synuclein aggregation, and basal-ganglia circuit disruption, yet leave unresolved the distinctive clinical architecture of the disorder: the coexistence of preserved cortical intention with...