Anupam Bandyopadhyay

Beyond Antibodies: Glypican‐3‐Targeting Peptides for Precision Hepatocellular Carcinoma Theranostics

ABSTRACT Glypican‐3 (GPC‐3) is a cell‐surface glycoprotein, highly expressed in hepatocellular carcinoma (HCC) but largely absent in normal adult liver tissues, making it a clinically compelling biomarker and therapeutic target. Although monoclonal antibodies and antibody‐drug co...

Leveraging Iodomethylboronic Ester Reactivity to Access Late-Stage Dehydroalanine and Dehydrovaline onto Peptides in Water

Abstract We report a mild, chemoselective late-stage conversion of cysteine and penicillamine residues into dehydroalanine (Dha) and dehydrovaline (ΔVal), respectively, in peptides via rapid bis-alkylation with the commercially available iodomethylboronic acid pinacol ester (IMBp...