Antonio N. Calabrese

Structural basis of the gating mechanism of the large-conductance mechanosensitive channel from Escherichia coli

Abstract The mechanosensitive channel of large conductance (MscL) is a tension-gated, pore-forming protein that acts as a safety valve to protect bacteria from osmotic lysis. Escherichia coli MscL (EcMscL) was the first mechanosensitive channel discovered and subsequently served...