António José Salgado

Modeling Parkinson’s Disease Through Combined DJ-1 Deficiency and Noradrenergic Degeneration

Parkinson’s disease (PD) is characterized by progressive degeneration of the nigrostriatal dopaminergic system while increasing evidence indicates that early pathology also involves the locus coeruleus (LC) and the noradrenergic system. However, whether LC degeneration increases...