Antonio Castrillo

Liver X receptor (LXR) signaling in macrophage inflammation and cardiometabolic disease.

Cardiometabolic diseases profoundly remodel tissue immune landscapes, characterized by the accumulation of diverse macrophage subtypes. Among these, lipid-associated macrophages (LAMs) have emerged as an important subset that is frequently observed in cardiometabolically affected...

Hypothyroidism Improves Survival in Experimental Peritonitis

Abstract Hypothyroidism decreases the basal metabolic rate. Using three models of peritonitis, intraperitoneal LPS plus Zymosan challenge, cecal slurry-induced intraperitoneal infection, and cecal ligation and puncture, we demonstrate that hypothyroid mice show enhanced survival...