Antonello Maruotti

Composite Likelihood Inference for Simultaneous Clustering and Dimensionality Reduction of Multivariate Mixed-Type Longitudinal Data

Abstract We propose a novel multivariate hidden Markov model (HMM) designed to analyze longitudinal mixed-type data comprising continuous and ordinal variables. Our model identifies and prioritizes discriminative dimensions, i.e., those useful for clustering, while separating the...

Molecular Pathogenesis, Global Epidemiological Trends, and Treatment Strategies for Pteropine Orthoreoviruses: A Narrative Review

Pteropine orthoreoviruses are emerging bat-borne zoonotic viruses of the genus Orthoreovirus (family Reoviridae), increasingly recognized as causes of acute respiratory disease in humans. Originally grouped with the largely non-pathogenic mammalian orthoreoviruses, they have chal...

Individualized statin associated type 2 diabetes risk estimation with a deep causal model

Statin therapy reduces cardiovascular risk, but recorded statin exposure is associated with subsequent type 2 diabetes (T2D) in some populations. Individualized risk estimation and separation of low-density lipoprotein cholesterol (LDL-C)-mediated from non-LDL components remain c...