Anton Hospach

Combined interleukin-1 blockade for central nervous system inflammation in children with severe cryopyrin-associated periodic syndromes

Cryopyrin-associated periodic syndromes (CAPS) are rare NLRP3-mediated autoinflammatory disorders driven by excessive interleukin-1 (IL-1) signalling [1]. Central nervous system (CNS) inflammation, including aseptic meningitis, papilledema and sensorineural hearing loss, characte...