Anthony J. Michael

Aspartate-dependent polyamine biosynthesis in bacteria: chemical synthesis of carboxypolyamines and mechanism-based design of hydroxylamine-containing inhibitors of carboxyspermidine decarboxylase

Abstract Biogenic polyamines spermidine, spermine and some of their derivatives are small organic polycations vitally important in all domains of life. Recent studies have demonstrated that polyamine biosynthesis is subject to convergent evolution and that some bacteria employ bi...