Annika Winbo

Hydrogel platforms for 3D cardiac tissue engineering and fibrotic disease modelling

Tissue engineering offers significant potential to advance the understanding and treatment of cardiac disease by generating in vitro models that recapitulate myocardial physiology in both healthy and diseased states. Specifically, hydrogel‐based systems have been widely employed...

Lysosomal signaling pathways influence heart rhythm, and regulate atrial function

AIMS: In the heart, endogenous nicotinic acid adenine dinucleotide phosphate (NAADP) triggers lysosomal calcium (Ca2+) release to augment sarcoplasmic reticulum (SR) Ca2+ sequestration, producing larger Ca2+ transients. However, the role of lysosomal Ca2+ signals in pacemaker act...