Annemieke Madder

Modular multifunctional 5HP2O linkers for the versatile assembly of protein-oligonucleotide conjugates

Abstract As complex biotherapeutics continue to evolve, the demand for single-site, multi-functionalized protein conjugates intensifies. Current methods often suffer from maleimide-related hydrolytic instability or require multi-step invasive protein modifications. Here, we estab...