Annal Epsiba

A Box–Behnken-Optimized Phytosomal Strategy for Diosgenin: Enhancing Oral Delivery and Antipsoriatic Efficacy in a Preclinical Model

Abstract Psoriasis is a chronic inflammatory skin disorder characterized by excessive keratinocyte proliferation and immune dysregulation, affecting patients’ quality of life. Diosgenin (DG) is a natural steroidal sapogenin with potent anti-inflammatory and immunomodulatory effec...