Anna Mandinova

A TERRA-NONO axis drives fibroblast reprogramming in cancer

The molecular mechanisms linking chromosome homeostasis to fibroblast reprogramming into cancer-associated fibroblasts (CAFs) remain poorly understood. Here, we identify a clinically relevant, telomere-associated nuclear pathway driving CAF activation across multiple human cancer...

mRNA Therapeutics for Skin Rejuvenation: From Aging Atlases to Clinical Translation

ABSTRACT Skin aging is a multifactorial process characterized by the progressive decline of tissue structure, function and regenerative capacity. Although numerous interventions have been developed to improve the clinical manifestations of aging, most primarily alleviate downstre...