Anna Marie Blom

Human factor H-related protein 5 modulates the classical and lectin complement pathways on selected host ligands

Abstract C4b-binding protein (C4BP) and factor H (FH) are the main soluble negative regulators of the classical/lectin (CP/LP) and alternative (AP) complement pathways, respectively. They do not only act in solution but also interact with host ligands such as C-reactive protein (...

Targeting C4d to overcome resistance to antibody-based immunotherapy: an in vitro study

Tumor cells often develop defense mechanisms that render them insensitive to consecutive administrations of therapeutic monoclonal antibodies. This study aimed to produce an antibody that preferentially binds resistant tumor cells and eliminates them by the complement system atta...