Anita T. Layton

Sexual dimorphisms in mechanisms of pressure natriuresis

Aim: The renal pressure-natriuresis response defines the blood pressure set point and maintains circulating volume. In male rats, the mechanisms involve trafficking and inactivation of renal proximal sodium transporters. Mechanisms may differ in females due to sex differences in...

Temporal misalignment of renal sodium transport promotes non-dipping blood pressure phenotypes

Non-dipping blood pressure (BP) phenotypes are strongly associated with cardiovascular and renal morbidity, yet the physiological mechanisms governing nocturnal BP dipping remain incompletely understood. Experimental evidence suggests important roles for circadian timing, renal s...