Angelito Enriquez Malicse

A Universal Balance and Feedback Framework for Cancer-Cell State Transitions A Node-Network Theory of Malignant Attractors, Cellular Reversion, and Regulatory-State Control (Version 1.1)

Abstract Cancer is commonly characterized by genetic mutations, epigenetic alterations, abnormal signaling, uncontrolled proliferation, altered metabolism, immune evasion, and disruption of cellular differentiation. Recent systems-biology research provides evidence that malignant...

Universal Balance and Feedback Framework, Self-Referential Ignorance, and the Principle of Belonging A Proposed Unified Theoretical Model of Systems, Feedback, Self-Reference, and Relational Connectivity

Abstract This paper presents a proposed unified theoretical framework integrating three conceptual components: the Universal Balance and Feedback Framework (UBFF), Self-Referential Ignorance (SRI), and the Principle of Belonging (PB). The central proposition is that many complex...

Universal Balance and Feedback Framework, Self-Referential Ignorance, and the Principle of Belonging A Proposed Unified Theoretical Model of Systems, Feedback, Self-Reference, and Relational Connectivity

Abstract This paper presents a proposed unified theoretical framework integrating three conceptual components: the Universal Balance and Feedback Framework (UBFF), Self-Referential Ignorance (SRI), and the Principle of Belonging (PB). The central proposition is that many complex...

The Principle of Belonging as a General Systems Principle From Non-Organic Matter to Biological and Social Organization

Abstract This paper develops the Principle of Belonging as a systems-theoretic hypothesis proposing that entities are not adequately understood solely as isolated objects but also through their relationships, positions, functions, and dependencies within larger systems. Although...