Angel Montero Carcaboso

Limited evidence for chemo- and radiosensitization by HDAC inhibitors in gliomasphere models of pediatric high-grade glioma

Abstract Purpose Pediatric high-grade glioma (pedHGG), including diffuse intrinsic pontine glioma (DIPG) and non-pontine diffuse midline glioma, remains uniformly lethal despite radiotherapy and, in some protocols, temozolomide (TMZ). Recurrent histone H3 mutations reducing H3K27...

CNS distribution and preclinical activity of the PI3K/AKT inhibitors inavolisib and ipatasertib in pediatric-type diffuse high-grade gliomas

Abstract Purpose Pediatric-type diffuse high-grade gliomas (pHGG) are aggressive, largely incurable malignancies often characterized by PI3K/AKT pathway activation. This study investigated whether the PI3K inhibitor inavolisib and the AKT inhibitor ipatasertib could achieve thera...