Andrew Thomas DeWan

Imputed Rare‐Variant Aggregate Analysis Is a Powerful Approach to Detect Genetic Associations

ABSTRACT Imputation can cost‐effectively generate genotypes for millions of variants. This study evaluated the power of performing rare‐variant aggregate association tests using imputed genotypes. UK Biobank exome‐sequence data and variants obtained via imputation using the HRC (...

Neonatal Dried Blood Spot Metabolomics Reveals Signatures of Early‐Onset Myeloproliferative Neoplasms

ABSTRACT The etiology of myeloproliferative neoplasms (MPN) is poorly understood. We investigated the possible role of early‐life exposures in the pathogenesis of MPN diagnosed among children and young adults in a population‐based case–control study in California. Untargeted meta...