Andrew Lee

CREST functions as a molecular bridge between neuron-specific enhancers and epigenetic regulators in mature motor neurons

Abstract Motor neuron development requires precise transcriptional regulation mediated in part by BAF (BRG1/BRM-associated factor) chromatin remodeling complexes. The neuron-specific BAF subunit CREST is critical for neuronal function and is mutated in some cases of amyotrophic l...