Andrew Kellum

Characterization of Regioisomeric Conjugates Arising from Pixantrone at AP Sites in DNA

Abstract Alkylation at N7 of guanine leads to formation of abasic (AP) sites in DNA. These equilibrate between α and β anomers and form conjugates with 6,9-bis[(2-aminoethyl)amino]benzo[g]isoquinoline-5,10-dione (Pixantrone, PIX). NMR revealed that these conjugates formed as regi...