Andrew B. Ward

Self-Assembling Nanoparticles to Assess Multivalent Interactions between Influenza A Virus Hemagglutinin and Glycan Surfaces

Abstract The multivalent display of surface glycoprotein hemagglutinin (HA) on Influenza A viruses (IAVs) enhances the overall binding avidity to sialylated glycans on host cell surfaces. While precomplexing HA trimers with antibodies increases multivalency and avidity, this meth...