Andreas Friebe

cGMP Signaling in Arterioles Revealed by FRET ‐Based Real‐Time Measurement in Mice In Vivo

ABSTRACT cGMP evokes arteriolar vasorelaxation and is generated in smooth muscle by the soluble guanylyl cyclase (sGC) stimulated by endothelial NO. Phosphodiesterases (PDEs) degrade cGMP and may contribute in diameter regulation. We examined arteriolar cGMP levels in real‐time i...