Andrea Rentmeister

AllostericInhibitors of Erythromycin Resistance MethyltransferaseReverse Antibiotic Resistance

Abstract Methylation of a critical adenine residue of the 23S rRNA residing in the nascent exit tunnel of the bacterial ribosome, by Erythromycin resistant methyltransferases (Erms), reduces binding of macrolide, lincosamide, and streptogramin B (MLSB) class of antibiotics and co...