Anastasia C. Manesis

Deciphering Interheme Electron-Transfer Pathways in a Diheme Peroxidase from Methane-Oxidizing Bacteria

Abstract Bis-FeIV-forming enzymes represent an emerging paradigm in high-valent heme iron chemistry, in which two hemes separated by 15–20 Å are both oxidized to the FeIV state. A tryptophan positioned between the two hemes in two out of the three known enzymes to form this state...