Ana C. Fonseca

DOPA-Based poly(ester amide)s−A Tunable Biomimetic Approach for Surgical Adhesive Design

Abstract Novel biomimetic surgical adhesives were prepared in this work by the straightforward incorporation of L-3,4-dihydroxyphenylalanine (DOPA) in poly(ester amide)s (PEAs). A library of DOPA-based PEAs (DOPA-PEAs) with varying compositions was successfully synthesized by sol...

Assessing the Immunological Safety of Silk Fibroin Nanoparticles: An In Vitro Study With Primary Human Immune Cells

Biomaterials for drug delivery must be biodegradable, nontoxic, and must not trigger inflammatory or immune responses. Silk fibroin (SF) is a natural polymer with exceptional mechanical strength and notable biological properties. In this study, the immunogenicity and inflammatory...