Amira Guizani

Fatal toxic epidermal necrolysis induced by high-dose methotrexate in T-cell acute lymphoblastic leukemia

IntroductionHigh-dose methotrexate (HD-MTX) is a cornerstone in the treatment of acute lymphoblastic leukemia but carries a risk of severe toxicity. Toxic epidermal necrolysis (TEN) is a rare life-threatening adverse reaction.Case reportWe report the case of a 15-year-old male wi...