Amir Abbas Tahami Monfared

From Biomarker Anchors to Disease-State Transitions: A Biologically Anchored Probabilistic Principal Component Analysis Framework for Alzheimer’s Disease Progression Modeling

To develop and validate a biomarker-anchored probabilistic principal component analysis (PPCA) framework for identifying biologically interpretable latent dimensions of Alzheimer’s disease (AD) and evaluating their utility for disease progression modeling. Data from 1058 particip...

Back to economic fundamentals: a welfare-based accounting framework for societal value in health technology assessment

Practical adoption of “novel” value elements in value assessment remains uneven, in part because components are often defined inconsistently and may overlap. We develop a welfare-grounded accounting framework to organize societal value components and clarify when proposed element...