Amgad N. Makaryus

Deep Learning Applied to 12-Lead ECGs for Detection of Structural, Metabolic and Systemic Disease

The 12-lead electrocardiogram (ECG) is inexpensive, noninvasive, and widely available, but conventional interpretation may not capture subtle signals related to cardiac structure, systemic physiology, and future risk. This review examines the use of deep learning–enabled ECG anal...

Cardiac Myosin-Binding Protein C in Cardiovascular Disease

Cardiac myosin-binding protein C (cMyBPC) is an important sarcomeric regulatory protein that plays a key role in myocardial contraction and relaxation. Through its interactions with thick and thin filament proteins, cMyBPC helps regulate cross-bridge cycling and contributes signi...

Weight Management Before Pregnancy to Reduce Cardiovascular Risk

Cardiovascular disease remains the leading cause of morbidity and mortality among women globally, with growing evidence suggesting that cardiovascular risk can begin developing well before pregnancy, even during the preconception period. Among the most significant contributing fa...