Américo Cerqueira

Decoding the Cellular Response to Methylthioadenosine Uncovers Novel Targets for Chronic Liver Disease

Progressive familial intrahepatic cholestasis type 3 (PFIC3), caused by MDR3 deficiency (MDR2 in mice), is a lethal pediatric liver disease characterized by early-onset persistent cholestasis, progressive fibrosis, cirrhosis, and eventual liver failure. MDR3 is a phosphatidylchol...