Ambica Baru

BRCA1 ‐mediated transcriptional repression of FABP3 – Implications for breast cancer progression and chemosensitivity

Transcriptional regulation of key target genes by BRCA1 is crucial for its diverse functions. Here, we report fatty acid-binding protein 3 (FABP3) as a novel BRCA1-repressible target gene. Functional BRCA1 represses FABP3 promoter activity while mutant BRCA1 breast cancer cell li...