Amanda Bryn Rolseth

Ca 2+ regulation of PMCA2 calcium pump expression in hair cells of Tmc1 deafness mutants

Mutations in transmembrane channel-like protein 1 (TMC1), the pore-forming component of the mechano-electrical transducer (MET) channel in auditory hair cells, cause cell death and deafness in 3-wk old mice. We studied mice with mutations Tmc1 p.T416K, p.M412K, p.D528N, and p.D56...