Alyn H. Morice

Central SP/NK-1 signalling mediate cold-aggravated cough hypersensitivity in guinea pigs

Research question Cold exposure commonly worsens chronic cough, but mechanisms linking peripheral cold sensing to central cough hypersensitivity remain unclear. We examined whether cutaneous transient receptor potential ankyrin 1 (TRPA1) signalling contributes to cold-aggravated...

The Genetic Architecture of Chronic Cough: From Sensory Hypersensitivity to Treatable Trait

Chronic cough is a prevalent global clinical disorder with substantial quality-of-life impairment, and refractory cases remain a major unmet medical need. Cough hypersensitivity syndrome is the core pathological mechanism of chronic cough, and growing genetic evidence has confirm...