Álvaro Gutiérrez-Uzquiza

The purinergic receptor P2Y 13 controls the activation and mode of division of adult ventricular–subventricular zone neural stem cells

ABSTRACT The subependymal zone (SEZ) of the mammalian brain is the most active germinal area that continues to generate newborn neurons throughout life. This area harbors a population of neural stem cells (NSCs) that can be found in different states of activation, each differing...

Development and validation of hypoxic chambers combined with an oxygen diffusion model for controlled radiobiological experiments

Abstract Tumor hypoxia is a hallmark of cancer that drives radioresistance, metastasis and poor clinical outcomes. In vitro modelling of hypoxic conditions is therefore critical for understanding tumor biology and testing therapeutic strategies. Commercially available hypoxic cha...