Allison M. Keeler

Chimeric Antigen Receptor (CAR) regulatory T cells effectively suppress autoimmune uveitis in presence of antigen

We evaluated the therapeutic efficacy of chimeric antigen receptor T regulatory (CAR Treg) cells to reduce ocular inflammation in a mouse model of experimental autoimmune uveitis (EAU). Engineered CAR Tregs that recognize adeno-associated virus (AAV) as antigen were delivered sys...