Alexey J. Merz

Sequential restriction of SNARE-mediated fusion by the COPII inner coat and SNARE chaperones

Abstract SNARE-mediated fusion requires assembly of four SNARE domains (R, Qa, Qb, and Qc) distributed across two membranes, with an SM (Sec1/Munc-18 family) chaperone catalyzing this assembly. We investigated topological requirements for the four SNAREs that mediate ER-Golgi fus...