Alexey A. Traspov

Panel-Specific Optimization and Benchmarking of Copy-Number Callers for ERBB2 Amplification Detection Using the Nanodigmbio NanOnco Plus Panel v3.0

Background/Objectives: ERBB2 amplification is a clinically relevant breast-cancer biomarker, but CNV detection from targeted sequencing depends on assay design, normalization, tumor fraction, and decision rules. We evaluated panel-specific ERBB2 analysis configurations against a...

Untargeted Metabolomic Profiling of Spermatozoa and Seminal Plasma Identifies Candidate Metabolic Indicators of Semen Quality in Holstein Bulls

This exploratory study applied untargeted LC–MS/MS metabolomic profiling to investigate metabolic differences between Holstein bulls with high-quality (HQ) and low-quality (LQ) semen in both spermatozoa and seminal plasma. Bulls were classified based on long-term routine semen qu...