Alexandria Louise Shaw

Molecular basis of phosphatidylinositol 4-kinase alpha (PI4KA) regulation by regulatory protein partners and post-translational modifications

Type III phosphatidylinositol 4-kinase alpha (PI4KA) is a lipid kinase that generates the primary pool of phosphatidylinositol 4-phosphate (PI4P) at the plasma membrane (PM). It is a master regulator of PM asymmetry and identity and provides PI4P substrate for downstream PI(4,5)P...