Alexandra V. Bruter

The sensitivity of acute myeloid leukemia to CDK8/19 inhibitors is determined by their metabolic profile

Cyclin-dependent kinases CDK8/19 are serine/threonine kinases that regulate transcription as part of the Mediator complex and phosphorylate several non-transcriptional substrates in both normal and tumor cells. Several studies have demonstrated that inhibition of CDK8/19 leads to...