Alexander Kai Buell

Probing the Energy Landscape of α‐Synuclein Amyloid Fibril Formation by Systematic K‐to‐Q Mutagenesis

ABSTRACT Aggregation of α‐synuclein (αSyn) is a hallmark of Parkinson's disease, yet its pathological roles remain poorly understood. Elucidating these roles requires detailed knowledge of the free energy landscape of αSyn self‐assembly, i.e. the states that can be populated and...