Alexander E. Marras

Impact of DNASequence and Structure on PolyelectrolyteComplex Micelle Morphology

Abstract Polyelectrolyte complex micelles (PCMs) are promising nucleic acid nanocarriers; however, nucleic acids are usually treated as generic polyanions, leaving the impact of nucleotide sequence and partially hybridized structures unclear. Here, we systematically tune DNA stif...

Co-Encapsulation of Indocyanine Green J-Aggregate and Paclitaxel in Biodegradable Polymersomes for Photoacoustic-Guided Chemotherapy

Abstract Treatment of solid tumors remains one of the biggest challenges in oncology. Targeted nanotherapeutics could significantly improve treatment efficacy and reduce side effects. However, their efficient implementation requires knowledge of pharmacokinetics (PK) and biodistr...