Alexander Bertuccioli

Gut Delivery of Pentameric GLP-1 Using Genetically Engineered Bacillus subtilis

Abstract Glucagon-like peptide-1 (GLP-1) receptor agonists and GLP-1 analogs are widely used for type 2 diabetes (T2D) and weight management, but current approaches can be limited by manufacturing complexity, cost, formulation requirements, and the need for repeated administratio...

Vaginal formulations selectively target Lactobacillus iners and Candida spp. while preserving Lactobacillus crispatus

Vaginal eubiosis is associated with low bacterial diversity and Lactobacillus crispatus dominance, whereas Lactobacillus iners often persists after antibiotics. We evaluated complementary approaches to inhibit L. iners and Candida spp. while preserving L. crispatus . Carbohydrate...

HPV DNA negativity following AHCC or nonavalent vaccination or their combination in women with persistent HPV infection without HSIL

Persistent infection with high-risk human papillomavirus (HR-HPV) is a common clinical condition for which no validated systemic antiviral therapy is currently available, and in the absence of high-grade cervical lesions management is generally limited to surveillance. Active Hex...