Alex Chia Yu Chang

Parturition attenuates endothelial senescence to resist nitrosative stress-induced heart failure with preserved ejection fraction in mice

Abstract Background Heart failure with preserved ejection fraction (HFpEF) accounts for 50% of heart failure patients and is biased toward elderly females. Nitrosative stress-induced HFpEF animal studies fail to phenocopy this sex bias and the underlying pathological mechanisms r...