Aleksandra Skirycz

Cystinosin/Ers1 functions in redox homeostasis in the early secretory pathway

Abstract Cystinosis is an autosomal recessive inherited disorder caused by mutations in the CTNS gene, which encodes the highly conserved transmembrane protein cystinosin, a proton/cystine co-transporter at the lysosome membrane. However, reduction of cystine load in the lysosome...