Alejandro J. Vila

Adaptive landscape of the metallo-β-lactamase NDM-1 to emerging β-lactam-based therapies

ABSTRACT The New Delhi metallo-β-lactamase (NDM) is a major determinant of carbapenem resistance. This has prompted the development of novel therapeutic strategies to treat NDM producers. Since these therapies impose new selective pressures, their clinical deployment may favor ND...

Beyond Catalysis: Physiology, Cellular Biology And Therapeutic Strategies for Metallo-β-Lactamase-Producing Pathogens

Abstract Metallo-β-lactamases (MBLs) are zinc-dependent β-lactamases that threaten the clinical utility of carbapenems and other last-line β-lactams in Gram-negative pathogens. Their impact cannot be explained solely based on their catalytic efficiency. Clinically relevant MBLs d...