Alastair I.H. Murchie

Cryo-EM structures of Cdr1 reveal snapshots of substrate transport and diverse inhibitor recognition

In Candida albicans —a World Health Organization fungal priority pathogen—overexpression of the adenosine triphosphate (ATP)–binding cassette transporter Cdr1 drives multidrug resistance. We present seven cryo–electron microscopy structures capturing substrate entry and expulsion...