Alain Zgheib

A SORT1-associated transcriptional signature links adipogenic plasticity, stemness and drug-resistance programs in 3D glioblastoma spheroids: dissection of ligand-dependent and ligand-independent arms

Three-dimensional (3D) culture of glioblastoma (GBM) cells recapitulates tumour-niche features lost in 2D monolayers, including stemness, metabolic plasticity and therapy resistance. By creating hydrophobic compartments that sequester lipophilic chemotherapeutics, increased adipo...